Oncomedicine 2017; 2:24-27. doi:10.7150/oncm.17486

Research Paper

Antiemetic Effects of Granisetron or Metoclopramide Administered Prior to Amrubicin Monotherapy

Takeshi Aoyama1,2✉, Kenichi Suzuki1, Takashi Tsunoda1, Kazuyoshi Kawakami1, Tomomi Takiguchi1, Hiroshi Watanabe1, Wataru Suzuki1, Kazuo Sugita1, Hitoshi Sato2, Erika Sugiyama2, Toshihiro Hama1, Makoto Nishio3

1. Department of Pharmacy, The Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo 135-8550, Japan.
2. Department of Drug Information, Division of Pharmacokinetics/Pharmacodynamics, School of Pharmacy, Showa University, Tokyo 142-8555, Japan.
3. Department of Thoracic Medical Oncology, The Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo 135-8550, Japan.

Abstract

Purpose: Amrubicin (AMR) is an anthracycline antitumor agent that has little cardiotoxicity and exhibits promising activity for small cell lung cancer (SCLC). Although AMR monotherapy is primarily used as a second-line treatment for SCLC in Japan, AMR-induced nausea and vomiting have not been definitively evaluated, and antiemetic therapy for AMR has yet to be established. This study retrospectively evaluated the antiemetic effects of granisetron or metoclopramide during AMR monotherapy.

Methods: We reviewed the medical records of SCLC patients who received AMR monotherapy at our hospital. Incidence of nausea and vomiting and the complete response (CR) of the anti-emesis, which was defined as the absence of any emetic episode or the use of any rescue medication, were evaluated.

Results: A total of 63 SCLC patients were treated with AMR monotherapy between April 2009 and November 2014. Antiemetic therapy was administered on days 1-3, with 33 patients receiving 3 mg of granisetron (Group G) and 30 patients receiving 20 mg of metoclopramide (Group M). Nausea and vomiting were observed in 30.3% of Group G and 30.0% of Group M patients. The CR rate observed was 78.7% in Group G and 73.3% in Group M. There were no significant differences between Groups G and M.

Conclusion: Both granisetron and metoclopramide were successfully used for anti-emesis during AMR monotherapy.

Keywords: Anti-emesis - Amrubicin monotherapy- Granisetron -Metoclopramide-Moderately emetic-risk chemotherapy.

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How to cite this article:
Aoyama T, Suzuki K, Tsunoda T, Kawakami K, Takiguchi T, Watanabe H, Suzuki W, Sugita K, Sato H, Sugiyama E, Hama T, Nishio M. Antiemetic Effects of Granisetron or Metoclopramide Administered Prior to Amrubicin Monotherapy. Oncomedicine 2017; 2:24-27. doi:10.7150/oncm.17486. Available from http://www.oncm.org/v02p0024.htm